PUBLICATIONS & RESOURCES
Select Publications & Resources
VINEx Media Coverage and Publications
September 20, 2021
Why the fight against COVID-19 won't end with a high vaccination rate
FP Economy essay series: 'Long COVID' threatens future productivity and profitability if leaders fail to take it seriously
September 2, 2021
VINEx and COVID Long Haulers Support Group Canada welcome Liberal Party of Canada's Commitment to allocate $100 million to COVID-19 research
This investment will bring hope and relief to the estimated hundreds of thousands of Canadians who are living with the devastating long-term effects of this virus on their health, and consequently on their family life, academic life or ability to work. The COVID-19 Research Fund will give a much-needed boost to Canada's world-class scientists and clinicians, who are converging across disciplines to advance research and care for COVID Long Haulers. We urge all political parties to make the support of COVID-19 research part of their platforms.
July 26, 2021
Don't let the two-dose summer fool you — there is a long battle ahead against COVID-19
Financial Post. Viruses, including SARS-CoV-2, can have devastating impacts on brain health.
June 25, 2021
The Long Haul: Episode 6 - Inez Jabalpurwala talks about the neurological effects of Long COVID
On June 25th, Dr. Jeremy Rossman interviewed VINEx Global Director Inez Jabalpurwala on the Zero Covid Alliance podcast The Long Haul. In the episode, Inez discusses the neurological and psychiatric impacts of Long COVID, and why we need to include people with lived experience as we set research and care priorities. Listen to the podcast.
June 25, 2021
Long-haul COVID sufferers report symptoms months after the initial infection, with no idea how long they'll last.
CBC's Matt Galloway speaks with COVID-19 long hauler Amber Spence, neurologist Andrew Josephson and VINEx Global Director Inez Jabalpurwala on the long-term brain impacts being experienced by an estimated 10-35% of those who contracted COVID-19.
JUNE 9, 2021
Report on Pan-Canadian Long Covid Impact Survey
Report on the survey conducted by Viral Neuro Exploration (VINEx), COVID Long Haulers Support Group Canada, and Neurological Health Charities Canada (NHCC) examining the impact of Long COVID.
June 3, 2021
Pan-Canadian Survey Reveals Long-term Harm of COVID to Brain Health
Viral Neuro Exploration (VINEx), COVID Long Haulers Support Group Canada, and Neurological Health Charities Canada (NHCC) announce the results of a pan-Canadian survey of more than 1,000 COVID long-haulers, revealing the impact of Long COVID on brain health.
February 5, 2021
Canada should lead the effort to help COVID long-haulers
The Globe and Mail. Inez Jabalpurwala, the global director of the Viral Neuro Exploration (VINEx) initiative, makes the case that COVID-19 research needs to include survivors of the pandemic that have a reduced quality of life and potentially lasting neurological impacts -- and that Canada can lead the way.
NOVEMBER 4, 2020
Be open to unexpected ideas: How Inez Jabalpurwala gives voice to outliers
Forbes. As the founding CEO of Brain Canada and now the global director of the Viral Neuro Exploration (known as “VINEx”), a social impact venture that was initiated by Rocket Science Health, a private medical device company, Jabalpurwala has been a catalyst, rallying and closely collaborating with a community of scientists from different fields and disciplines.
August 12, 2020
How does COVID-19 affect the nervous system? Canadian and international scientists want to find out.
The Globe and Mail. Brought together as part of a new initiative called VINEx, created by Rocket Science Health, a Victoria-based medical devices company, the group is aiming to lead the charge in understanding how viruses invade the brain – an area of study that has received relatively little attention.
August 17, 2020
How is COVID-19 affecting people's brains.
The Adam Stirling Show (CFAX 1070). There are many unknowns about Covid-19 and the effect it has on the brains of patients is one of them. Inez Jabalpurwala, Global Director for VINEx, spoke with Adam about a multi-disciplinary exploration of the virus-brain connection.
SEPTEMBER 1, 2020
Dr. Robyn S. Klein MD, PhD Joins VINEx Science Advisory Council.
Rocket Science Health today announced that Robyn S. Klein, MD, PhD, has joined the Science Advisory Council (SAC) for VINEx.
AUGUST 13, 2020
Rocket Science Health and Inez Jabalpurwala team up to launch VINEx. A Multi-disciplinary exploration of the virus-brain connection.
VINEx to Provide Catalytic Leadership for Research into a Vital Area in the Fight Against SARS-CoV-2 and other Viruses which may have Lasting Effects on the Brain.
VINEx Grapevine newsletter
EXTERNAL SCIENTIFIC LITERATURE
Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP).
Horn A. et al. Infection. October 12, 2021.
Assessment of Cognitive Function in Patients After COVID-19 Infection
Becker, J. JAMA Network Open. October 22, 2021
Long-COVID: neurological manifestations and management
Williams, S. et al. Journal of Neurology. October 11, 2021
Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
Groff, D et al. JAMA Network Open. October 13, 2021
Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions
Beghi, E. Journal of Neurology. October 21, 2021.
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene
Magusali, N et al. Brain. October 7, 2021.
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
Taquet, M et al. Plos Medicine. September 28, 2021
Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections
Sparrer et A. Cells. August 19, 2021
More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
Villapol S. Et al. Scientific Reports. August 9, 2021.
Neuro-COVID long-haulers exhibit broad dysfunction in T cell memory generation and responses to vaccination
Visvabharathy L. et al. medRxiv. August 9, 2021.
Post-viral effects of COVID-19 in the olfactory system and their implications
Xydakis. M et al. The Lancet Neurology. July 30, 2021.
SARS-CoV-2 Susceptibility and COVID-19 Mortality Among Older Adults With Cognitive Impairment: Cross-Sectional Analysis From Hospital Records in a Diverse US Metropolitan Area
Pan. A et al. Frontiers in Neurology. July 22, 2021.
Cognitive deficits in people who have recovered from COVID-19.
Hampshire, R. et al. Eclinical Medicine. July 22, 2021.
Characterizing long COVID in an international cohort: 7 months of symptoms and their impact Hannah E. Davis 1
Davis, H et al. Eclinical Medicine. July 15, 2021
Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study
Menges, D et al. PLoS One. July 12, 2021
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
Ramakrishnan, R et al. Frontiers in Immunology. June 30, 2021.
Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort
Sipila, P et al. The Lancet Infectious Diseases. June 21, 2021
The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection
Moghimi, Narges et al. “The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection.” Current neurology and neuroscience reports vol. 21,9 44. 28 Jun. 2021, doi:10.1007/s11910-021-01130-1
Brain imaging before and after COVID-19 in UK Biobank
Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro-Almagro, Christoph Arthofer, Chaoyue Wang, Frederik Lange, Jesper L.R. Andersson, Ludovica Griffanti, Eugene Duff, Saad Jbabdi, Bernd Taschler, Anderson Winkler, Thomas E. Nichols, Rory Collins, Paul M. Matthews, Naomi Allen, Karla L. Miller, Stephen M. Smith
medRxiv June 11, 2021; doi: https://doi.org/10.1101/2021.06.11.21258690
Prevalence of long-term effects in individuals diagnosed with COVID-19: a living systematic review
Francesca Reyes Domingo, Lisa A Waddell, Angela M. Cheung, Curtis L. Cooper, Veronica J. Belcourt, Alexandra M. E. Zuckermann, Tricia Corrin, Rukshanda Ahmad, Laura Boland, Claudie Laprise, Leanne Idzerda, Anam Khan, Alejandra Jaramillo Garcia
medRxiv, June 2, 2021; doi: https://doi.org/10.1101/2021.06.03.21258317
Attributes and predictors of long COVID
Sudre, C.H., Murray, B., Varsavsky, T. et al. Attributes and predictors of long COVID. Nat Med 27, 626–631 (2021).
Approaches to understanding COVID‐19 and its neurological associations
Beghi, E., Michael, B., Solomon, T., Westenberg, E., Winkler, A. Annals of Neurology. April 9, 2021.
doi: 10.1002/ana.26076.
6-month neurological and psychiatric outcomes in 236,379 survivors of COVID-19: a retrospective cohort study using electronic health records
LEARN MOREPost-acute COVID-19 syndrome
Nalbandian, A., Sehgal, K., Gupta, A. et al. 2021. Nature Medicine. https://doi.org/10.1038/s41591-021-01283-z
Neurological infection with SARS-CoV-2 — the story so far
Solomon, T. Nat Rev Neurol 17, 65–66 (2021). https://doi.org/10.1038/s41582-020-00453-w
The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning
LEARN MORENeuroCOVID: it's time to join forces globally
Helbok, R., Chou, S., Beghi, E., Mainali, S., Frontera, J., Robertson, C., Fink, E., Schober, M., Moro, E., McNett, M. and Bassetti, C., 2021. The Lancet Neurology.
Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62,354 COVID-19 cases in the USA
LEARN MOREA systematic review of neurological symptoms and complications of COVID-19
Chen X, Laurent S, Onur OA, et al. J Neurol. 2020;1-11. doi:10.1007/s00415-020-10067-3
Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review
Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. JAMA Neurol. Published online May 29, 2020. doi:10.1001/jamaneurol.2020.2065
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China
Mao L, Jin H, Wang M, et al. JAMA Neurol. 2020;77(6):683–690. doi:10.1001/jamaneurol.2020.1127
SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.
Butowt R, Bilinska K. ACS Chem Neurosci. 2020;11(9):1200-1203. doi:10.1021/acschemneuro.0c00172
Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.
Holmes, Emily A et al. The Lancet Psychiatry, Volume 7, Issue 6, 547 – 560
Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies.
Misra, S. et al. Preprint. medRxiv. April 23, 2021. https://doi.org/10.1101/2021.04.20.21255780
High-dimensional characterization of post-acute sequalae of COVID-19
Al-Aly, Z., Xie, Y. Bowe, B. Nature. April 22, 2021
From our Science Advisory Council Members
Uncertainty around the Long-Term Implications of COVID-19
Desforges M, Gurdasani D, Hamdy A, Leonardi AJ. Pathogens. October 1, 2021.
A Call for International Research on COVID Induced Brain Disorders
Valdes-Sosa, P; Evans, A; Valdes-Sosa, M; Poo, M. National Science Review. October 27, 2021.
Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease
Balcom EF, Nath A, Power C. Brain. 2021 Aug 16:awab302. doi: 10.1093/brain/awab302. Online ahead of print.
New research adds to calls for better support for long COVID patients
June 21, 2021 - Ottawa Citizen
How COVID-19 Affects the Brain
Boldrini M, Canoll PD, Klein RS. How COVID-19 Affects the Brain. JAMA Psychiatry. Published online March 26, 2021. doi:10.1001/jamapsychiatry.2021.0500
COVID-19 Neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital (PREPRINT)
Thakur K et al (Klein RS). Preprint. Published online March 21, 2021. doi.org/10.1101/2021.03.16.21253167
The impact of SARS‐CoV‐2 in dementia across Latin America: A call for an urgent regional plan and coordinated response
Ibanez A, Santamaria-Garcia H, Guerrero Barragan A, et al. Alzheimers Dement (N Y). 2020;6(1):e12092. Published 2020 Nov 23. doi:10.1002/trc2.12092
Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease
Serrano GE, Walker JE, Arce R, et al. Preprint. medRxiv. 2021;2021.02.15.21251511. Published 2021 Feb 18. doi:10.1101/2021.02.15.21251511
Potential differences in cleavage of the S protein and type-1 interferon together control human coronavirus infection, propagation, and neuropathology within the central nervous system
Alain Le Coupanec, Marc Desforges, Benedikt Kaufer, Philippe Dubeau, Marceline Côté, Pierre J. Talbot. Journal of Virology. Feb 2021, JVI.00140-21; DOI: 10.1128/JVI.00140-21
Microvascular Injury in the Brains of Patients with Covid-19
Lee M-H, Perl DP, Nair G, et al. New England Journal of Medicine. 2021;384(5):481-483. doi:10.1056/nejmc2033369
Neurological issues during COVID-19: An overview
Nath A, Smith B. Neurosci Lett. 2021;742:135533. doi:10.1016/j.neulet.2020.135533
Is COVID-19 a Perfect Storm for Parkinson's Disease?
Brundin P, Nath A, Beckham JD. Trends Neurosci. 2020;43(12):931-933. doi:10.1016/j.tins.2020.10.009
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System.
Desforges M, Le Coupanec A, Dubeau P, et al. Viruses. 2019;12(1):14. Published 2019 Dec 20. doi:10.3390/v12010014
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System
De Felice, Fernanda G. et al. Trends in Neurosciences, Volume 43, Issue 6, 355 – 357
Neurologic complications of coronavirus infections.
Nath, Avindra. Neurology. May 2020, 94 (19) 809-810; DOI: 10.1212/WNL.0000000000009455
News Resources - Neurological effects of COVID-19
Post-illness symptoms like long Covid are probably more common than we think
September 12, 2021 - The Guardian
Preliminary research finds that even mild cases of COVID-19 leave a mark on the brain – but it’s not yet clear how long it lasts
September 24, 2021 - The Conversation
More than 150,000 people in Canada experience 'long COVID' symptoms, report estimates
September 15 - CBC News
Related report - Understanding the Post COVID-19 Condition (Long COVID) and the Expected Burden for Ontario
NIH builds large nationwide study population of tens of thousands to support research on long-term effects of COVID-19
September 15, 2021 - NIH News Release
The long tail of COVID-19: Doctors, patients coming to grips with long COVID
September 8, 2021 - Ottawa Citizen
COVID-19 could serve as a 'Trojan horse' for dementia and Alzheimer's, experts say
August 31, 2021 - CTV News
How does COVID-19 affect the brain? A troubling picture emerges.
August 18, 2021 - National Geographic
How does COVID affect the brain? Two neuroscientists explain
August 10, 2021 - The Conversation
What Causes Long COVID Symptoms? NYU Langone Researchers Net $52 Million Federal Grant to Find Out
June 10, 2021 - NYU Langone Health News Hub
COVID-19 affects men and women differently. So why don’t clinical trials report gender data?
July 6, 2021 - Science
Doctors Worry That Memory Problems After COVID-19 May Set The Stage For Alzheimer's
July 26, 2021 - NPR News
Brain fog to night sweats: Long COVID has more than 200 symptoms, study finds
July 15, 2021 - National Post
Like polio, the long-term impact of COVID will be measured in disability
September 29, 2021 - CNN
A Tsunami of Disability Is Coming as a Result of ‘Long COVID’
July 6, 2021 - Scientific American
Long COVID has exposed medicine's blind-spot
June 18, 2021 - The Lancet - Infectious Diseases
It’s Not Over ’Til It’s Over: Prevalence Of Long-Term Symptoms In Individuals Diagnosed With Covid-19
based on the following journal article:
Prevalence of long-term effects in individuals diagnosed with COVID-19: a living systematic review
June 15, 2021 - COVID-19 Immunity Task Force
Cleveland Clinic-led Study Identifies How COVID-19 Linked to Alzheimer’s Disease-like Cognitive Impairment
June 10th, 2021 - Cleveland Clinic Newsroom
Scientists begin to unravel the mysteries of the coronavirus and brains
June 7th, 2021 - Washington Post
Understanding The Neurological And Psychological Effects Of Covid-19
April 29, 2021 - Forbes
Covid-19 gave scientists an opening to better understand how brain disorders arise
April 26, 2021 - Stat
Une étude montréalaise pour mieux comprendre la COVID-19 longue
April 16, 2021 - Quebec Science
A Close Look at How COVID-19 Infection Can Damage the Brain
April 15, 2021 - Brain and Behavior Research Foundation Blog
Psychiatric and neurological problems are common in COVID-19’s wake, study finds
April 8, 2021 - Los Angeles Times
'Brain fog' and other neurologic symptoms can last for months after Covid
March 23, 2021 - NBC News
In the wake of the pandemic: preparing for Long COVID (2021)
February 25, 2021 - WHO policy Brief
COVID-19 Could Increase Dementia, Other Brain Disorders for Decades to Come
February 10, 2021 - Newsweek
Taking a Closer Look at COVID-19’s Effects on the Brain
January 14, 2021 - NIH Director's Blog
COVID-19 long-haulers: Canada's forgotten patients
January 23, 2021 - CBC Marketplace
Related Article: 60% of COVID-19 long-haulers say government is 'absolutely ignoring them,' Marketplace questionnaire finds. CBC
We're about to see a wave of long Covid. When will ministers take it seriously?
January 21, 2021 - The Guardian
One in 5 COVID-19 patients develop mental illness within 90 days -study
November 9, 2020 - Reuters
Covid Survivors With Long-Term Symptoms Need Urgent Attention, Experts Say
December 4, 2020 - New York Times
Long after the fire of a Covid-19 infection, mental and neurological effects can still smolder
August 12, 2020 - Stat
'I Feel Like I Have Dementia’: Brain Fog Plagues Covid Survivors.
October 11, 2020 - New York Times
ORGANIZATIONS OF INTEREST
Long-COVID Alliance
LEARN MORECOVID Long Haulers Support Group Canada
LEARN MOREInternational Severe Acute Respiratory and Emerging Infection Consortium
LEARN MORESurvivor Corps
A grassroots organization to connect and mobilize COVID-19 survivors to engage in research studies to further our understanding of long-term effects of the disease.
Brain Infections Global
LEARN MOREADDITIONAL SARS-COV-2 LITERATURE RESOURCES
Viruses and the Brain
Multiple sclerosis: the link with earlier infection just got stronger – new study
The Conversation - October 11, 2021.
New evidence shows how viral infections could promote Alzheimer’s
New Atlas - October 19, 2021.
Parkinson’s strikes more men than women. Researchers have worked for decades to learn why
Washington Post - July 4, 2021