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Insights & Resources 

NEWS & MEDIA

AUGUST 13, 2020

Rocket Science Health and Inez Jabalpurwala team up to launch VINEx. A Multi-disciplinary Exploration of the Virus-Brain Connection.

VINEx to Provide Catalytic Leadership for Research into a Vital Area in the Fight Against SARS-CoV-2 and other Viruses which may have Lasting Effects on the Brain.

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SEPTEMBER 1, 2020

Dr. Robyn S. Klein MD, PhD Joins VINEx Science Advisory Council.

Rocket Science Health today announced that Robyn S. Klein, MD, PhD, has joined the Science Advisory Council (SAC) for VINEx.

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August 17, 2020

How is COVID-19 Affecting People's Brains.

The Adam Stirling Show (CFAX 1070). There are many unknowns about Covid-19 and the effect it has on the brains of patients is one of them. Inez Jabalpurwala, Global Director for VINEx, spoke with Adam about a multi-disciplinary exploration of the virus-brain connection. 

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August 12, 2020

How does COVID-19 affect the nervous system? Canadian and international scientists want to find out.

The Globe and Mail. Brought together as part of a new initiative called VINEx, created by Rocket Science Health, a Victoria-based medical devices company, the group is aiming to lead the charge in understanding how viruses invade the brain – an area of study that has received relatively little attention.

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SELECTED LITERATURE RESOURCES

The burden of neurological disease and psychiatric disorders

Any Mood Disorder. National Institute of Mental Health.

Any Mood Disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/statistics/any-mood-disorder.shtml. Accessed July 27, 2020.

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Depression. The World Health Organization.

Depression. The World Health Organization. https://www.who.int/news-room/fact-sheets/detail/depression. Accessed July 27, 2020.

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Mental Health and Development: Targeting People with Mental Health Conditions as A Vulnerable Group.

Funk M, Drew N, Freeman M, Faydi E. Mental Health and Development: Targeting People with Mental Health Conditions as A Vulnerable Group. Geneva, Switzerland: World Health Organization; 2010.

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Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):459‐480. Doi:10.1016/S1474-4422(18)30499-X

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Neurological Disorders: Public Health Challenges.

WHO. Neurological Disorders: Public Health Challenges. Geneva, Switzerland: World Health Organization, WHO Press; 2006.

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Drug delivery to the central nervous system

Mechanism of intranasal drug delivery directly to the brain.

Crowe TP, Greenlee MHW, Kanthasamy AG, Hsu WH. Mechanism of intranasal drug delivery directly to the brain. Life Sci. 2018;195:44-52. doi:10.1016/j.lfs.2017.12.025

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Evaluation of intranasal delivery route of drug administration for brain targeting.

Erdő F, Bors LA, Farkas D, Bajza Á, Gizurarson S. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Research Bulletin. 2018;143:155-170. doi:10.1016/j.brainresbull.2018.10.009

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The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes

Gribkoff VK, Kaczmarek LK. The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes. Neuropharmacology. 2017;120:11-19. doi:10.1016/j.neuropharm.2016.03.021

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The blood-brain barrier: bottleneck in brain drug development.

Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2005;2(1):3‐14. doi:10.1602/neurorx.2.1.3

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Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders.

Islam SU, Shehzad A, Ahmed MB, Lee YS. Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders. Molecules. 2020;25(8):1929. Published 2020 Apr 21. doi:10.3390/molecules25081929

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Challenges in drug delivery to the olfactory region

Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions.

Calmet H, Inthavong K, Eguzkitza B, Lehmkuhl O, Houzeaux G, et al. (2019) Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions. PLOS ONE 14(9): e0221330.

https://doi.org/10.1371/journal.pone.0221330

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Modeling of release position and ventilation effects on olfactory aerosol drug delivery.

Si XA, Xi J, Kim J, Zhou Y, Zhong H. Modeling of release position and ventilation effects on olfactory aerosol drug delivery. Respir Physiol Neurobiol. 2013;186(1):22-32. doi:10.1016/j.resp.2012.12.005 

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Improving intranasal delivery of neurological nanomedicine to the olfactory region using magnetophoretic guidance of microsphere carriers.

Xi J, Zhang Z, Si XA. Improving intranasal delivery of neurological nanomedicine to the olfactory region using magnetophoretic guidance of microsphere carriers. Int J Nanomedicine. 2015;10:1211‐1222. Published 2015 Feb 10. doi:10.2147/IJN.S77520

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